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. 2011 Sep 19;6(9):e24102. doi: 10.1371/journal.pone.0024102

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Yamaguchi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Five million PPC-1 human prostate cancer cells were xenografted onto nude mice as described in the text and the method. a, Mice Tumor volumes were measured in mice (n = 7 per group) treated with diluent only (group A), 2DG (group B), ABT-263 (group C), 2DG plus ABT-263 (group D), or 2DG mixed with D-glucose plus ABT-263 (group E), as explained in the text, where drugs were administered 3 times weekly between day 9 and 27 (gray rectangles). b, Survival of tumor-bearing mice was determined at various times post-inoculation with PPC-1 cells. The % of surviving mice is indicated from groups A-E (n = 7 per group). The difference of survival days between Group C & D versus Group E is p = 0.0283, 95% confidence interval of this difference: from −20.98 to −1.36 by unpaired t-test.