Figure 3. HCV infection induces prolonged activation of the UPR.

HCV infected HuH7.5.1 cells were grown in culture for 14 days and compared to non-infected cells and day 1 post-infection cells. Cells were harvested, RNA extracted and gene expression levels were determined by real-time PCR and normalized to b-actin expression. Results are means±S.D. of 3 independent experiments. * = p<0.05 (ANOVA, one way) for day 14 versus non-infected and day 1 infected cells.