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. 2011 Sep 19;6(9):e24660. doi: 10.1371/journal.pone.0024660

Figure 4. HCV-induced chronic ER stress confers resistance to drug induced UPR.

Figure 4

HCV infected cells were stimulated by decreasing doses of thapsigargin at day 5 and at day 14 post infection and the effect of stimulation on (a) XBP-1 splicing or (b) IRE1 and (c) eIF2α phosphorylation was assessed by RT-PCR and immunoblotting respectively. Quantification of the results was obtained from densitometric scanning of the blots (means±S.D.) of 3 experiments. * = p<0.05 (ANOVA, one way) for day 5 versus day 14 post infection.