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. 2011 Sep 19;6(9):e24922. doi: 10.1371/journal.pone.0024922

Figure 4. Differential expression of putative miR-34b target genes in miR-34b–expressing melanoma cells.

Figure 4

A) A heat-map of the top potential miR-34b targets suggested by TargetScan 5.1, based on fold change and transcript differences between WM1552C/34b cells vs. WM1552C/VO cells. Green boxes indicate gene targets associated with the network of cytoskeletal rearrangement shown in (B). B) Pathway mapping of the top potential miR-34b targets reveals 15 targets all associated with the network of cytoskeletal rearrangement. Targets are indicated in green. C) qRT-PCR validation of the differential expression of putative miR-34b targets CDC42 and FN1 in vector-transfected or miR-34b-transfected WM1552C cells. Values are listed as relative quantities (RQ).