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. 2011 Nov 1;15(9):2529–2541. doi: 10.1089/ars.2011.3974

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Copyright 2011, Mary Ann Liebert, Inc.

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FIG. 3. — Lifelong wheel running provides partial protection against age-associated downregulation of IGF-1 (51). IGF-1 protein expression in young (6 months) Fischer-344 rats fed ad libitum (YAL), old (24 months) rats fed ad libitum (OAL), old rats that underwent lifelong 8% caloric restriction (OCR), and old rats that participated in lifelong voluntary wheel running plus 8% caloric restriction (OExCR). Values are means ±SEM. (a) indicates significant difference from YAL group. (b) indicates significant difference from OAL group. IGF-1, insulin-like growth factor-1.