FIG. 2.

Doxorubicin depresses skeletal muscle force. Hindlimb muscles were obtained from rats 15 days after daily injections of doxorubicin (1.15 mg/kg/day). Muscles were placed in a tissue bath and isometric contraction measurements were made with a force transducer. Doxorubicin depressed force (N/cm²) in both the EDL (A) and soleus (B) muscles. Open symbols represent the doxorubicin group, closed symbols represent the saline injected controls (n=6–9 muscles for each group). Data are mean±SEM. ^ap<0.05, ^bp<0.01 vs. control. [From Ertunc et al. (71); reprinted with permission from S. Karger AG, Basel].