FIG. 2.

Effect of in vivo TN challenge (1 or 3 mg/kg, i.p. for 48 h) on intracellular Ca²⁺ properties in cardiomyocytes from WT and MyAkt mice. (A) Representative intracellular Ca²⁺ transients in cardiomyocytes from WT mice with or without TN; (B) representative intracellular Ca²⁺ transients in cardiomyocytes from MyAkt mice with or without TN; (C) resting fura-2 fluorescence intensity (FFI); (D) electrically stimulated increase in FFI (ΔFFI); (E) intracellular Ca²⁺ decay rate (single exponential); and (F) intracellular Ca²⁺ decay rate (biexponential). Mean±SEM, n=60 cells per group, *p<0.05 versus WT group; ^#p<0.05 versus respective WT-TN group.