. 2011 Jun 5;60(10):1419–1430. doi: 10.1007/s00262-011-1028-0

Table 3.

Bio-plex assay of plasma cytokines in controls and cancer patients

Number patients median (range) P value	Control N = 33	Pancreas N = 43	Esophagus N = 52	Gastric N = 24	UGI cancer N = 119
IL-2	21.1 (0, 4434.9)	90.7 (0, 6254.2) P = 0.38	70.6 (0, 6085.6) P = 0.16	82.6 (0, 2543.0) P = 0.26	81.6 (0, 6254.2) P = 0.17
IL-4	1.2 (0, 47.4)	0 (0, 190.5) P = 0.87	0 (0, 32.8) P = 0.020 (ns)	8.7 (0, 123.2) P = 0.0061	0 (0, 190.5) P = 0.84
IL-5	0 (0, 117.0)	7.4 (0, 883.2) P = 0.004	10.6 (0, 96.8) P < 0.001	10.2 (2.7, 242.2) P < 0.001	9.6 (0, 883.2) P < 0.001
IL-6	86.3 (8.6, 2038.3)	211.3 (30.7, 9352.1) P < 0.001	184.1 (24.7, 4606.9) P < 0.001	234.0 (13.5, 3009.3) P = 0.0029	197.6 (13.5, 9352.1) P < 0.001
IL-10	16.8 (0, 214.5)	39.7 (0.3, 918.7) P < 0.001	38.0 (0, 668.7) P < 0.001	63.8 (5.7, 433.0) P < 0.001	42.9 (0.3, 918.7) P < 0.001
IL-12 (p70)	135.4 (0, 651.4)	149.9 (0, 12714.9) P = 0.41	208.5 (0, 9696.6) P = 0.074	363.3 (0, 6967.5) P = 0.0026	201.6 (0, 12714.9) P = 0.038 (ns)
IL-13	27.5 (0, 148.5)	112.6 (0, 2140.0) P < 0.001	74.9 (7.6, 742.6) P < 0.001	84.4 (7.6, 715.2) P < 0.001	87.0 (0, 2140.0) P < 0.001
IL-17	0 (0, 341.8)	0 (0, 143.8) P = 0.31	0 (0, 427.3) P = 0.56	0 (0, 460.5) P = 0.37	0 (0, 460.5) P = 0.36
GCSF	51.6 (0, 235.9)	52.6 (0, 328.9) P = 0.92	19.8 (0, 249.9) P = 0.021 (ns)	53.6 (2.6, 153.0) P = 0.58	39.7 (0, 328.9) P = 0.35
IFN-γ^a	876.7 (0, 25060.4)	192.6 (0, 10926923.8) P = 0.11	890.8 (0, 26288.0) P = 0.51	1311.6 (0, 128613.3) P = 0.25	725.8 (0, 10926923.8) P = 0.48
TNF-α^a	29.0 (0, 1422.5)	36.7 (0, 16113.4) P = 0.67	0 (0, 2167.3) P = 0.046 (ns)	50.9 (0, 3730.7) P = 0.33	27.3 (0, 16113.4) P = 0.61
VEGF^a	798.5 (214.7, 4378.3)	1232.1 (0, 6957.3) P = 0.068	2120.2 (160.8, 14459.6) P < 0.001	2322.7 (315.7, 11915.6) P < 0.001	1711.1 (0, 14459.6) P < 0.001

Number patients median (range) P value

Control N = 33

Pancreas N = 43

Esophagus N = 52

Gastric N = 24

UGI cancer N = 119

IL-2

21.1

(0, 4434.9)

90.7

(0, 6254.2)

P = 0.38

70.6

(0, 6085.6)

P = 0.16

82.6

(0, 2543.0)

P = 0.26

81.6

(0, 6254.2)

P = 0.17

IL-4

1.2

(0, 47.4)

(0, 190.5)

P = 0.87

(0, 32.8)

P = 0.020 (ns)

8.7

(0, 123.2)

P = 0.0061

(0, 190.5)

P = 0.84

IL-5

(0, 117.0)

7.4

(0, 883.2)

P = 0.004

10.6

(0, 96.8)

P < 0.001

10.2

(2.7, 242.2)

P < 0.001

9.6

(0, 883.2)

P < 0.001

IL-6

86.3

(8.6, 2038.3)

211.3

(30.7, 9352.1)

P < 0.001

184.1

(24.7, 4606.9)

P < 0.001

234.0

(13.5, 3009.3)

P = 0.0029

197.6

(13.5, 9352.1)

P < 0.001

IL-10

16.8

(0, 214.5)

39.7

(0.3, 918.7)

P < 0.001

38.0

(0, 668.7)

P < 0.001

63.8

(5.7, 433.0)

P < 0.001

42.9

(0.3, 918.7)

P < 0.001

IL-12 (p70)

135.4

(0, 651.4)

149.9

(0, 12714.9)

P = 0.41

208.5

(0, 9696.6)

P = 0.074

363.3

(0, 6967.5)

P = 0.0026

201.6

(0, 12714.9)

P = 0.038 (ns)

IL-13

27.5

(0, 148.5)

112.6

(0, 2140.0)

P < 0.001

74.9

(7.6, 742.6)

P < 0.001

84.4

(7.6, 715.2)

P < 0.001

87.0

(0, 2140.0)

P < 0.001

IL-17

(0, 341.8)

(0, 143.8)

P = 0.31

(0, 427.3)

P = 0.56

(0, 460.5)

P = 0.37

(0, 460.5)

P = 0.36

GCSF

51.6

(0, 235.9)

52.6

(0, 328.9)

P = 0.92

19.8

(0, 249.9)

P = 0.021 (ns)

53.6

(2.6, 153.0)

P = 0.58

39.7

(0, 328.9)

P = 0.35

IFN-γ^a

876.7

(0, 25060.4)

192.6

(0, 10926923.8)

P = 0.11

890.8

(0, 26288.0)

P = 0.51

1311.6

(0, 128613.3)

P = 0.25

725.8

(0, 10926923.8)

P = 0.48

TNF-α^a

29.0

(0, 1422.5)

36.7

(0, 16113.4)

P = 0.67

(0, 2167.3)

P = 0.046 (ns)

50.9

(0, 3730.7)

P = 0.33

27.3

(0, 16113.4)

P = 0.61

VEGF^a

798.5

(214.7, 4378.3)

1232.1

(0, 6957.3)

P = 0.068

2120.2

(160.8, 14459.6)

P < 0.001

2322.7

(315.7, 11915.6)

P < 0.001

1711.1

(0, 14459.6)

P < 0.001

Number of patients (N), median, (Range), Wilcoxon rank sum test P value of cancer group versus control. The UGI (upper gastrointestinal) cancer group consists of the pancreatic, esophageal and gastric cancer patients combined. Bonferonni correction applied due to multiple testing with the control arm, statistical significance adjusted to P < 0.0125

^aLogarithmic transformations applied