Table 1.
Gas exchange, arterial oxygen content, cerebral oxygen consumption, and oxygen delivery.
| Fetal life | Postnatal life | Two-way ANOVA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B | HI | V | 15 min | 30 min | 60 min | 90 min | 120 min | 150 min | 180 min | |||
| pH | Control | 7.3 ± 0.06 (n = 6) |
7.30 ± 0.06 (n = 6) |
7.05 ± 0.07 (n = 6) |
7.12 ± 0.11 (n = 6) |
7.27 ± 0.17 (n = 6) |
7.28 ± 0.17 (n = 6) |
7.38 ± 0.15 (n = 6) |
7.43 ± 0.15 (n = 6) |
7.43 ± 0.13 (n = 6) |
7.37 ± 0.11 (n = 6) |
|
| HI | 7.3 ± 0.06 (n = 6) |
7.07 ± 0.04* (n = 6) |
6.89 ± 0.12* (n = 6) |
7.02 ± 0.15 (n = 6) |
7.11 ± 0.11 (n = 6) |
7.18 ± 0.09 (n = 6) |
7.26 ± 0.13 (n = 6) |
7.32 ± 0.12 (n = 6) |
7.33 ± 0.09 (n = 6) |
7.28 ± 0.08 (n = 6) |
||
| F(1,10) F = 0.7 | F(1,10) F = 98 | F(1,10) F = 8.1 | F(1,10) F = 1.74 | F(1,10) F = 3.4 | F(1,10) F = 1.6 | F(1,10) F = 2.2 | F(1,10) F = 1.8 | F(1,10) F = 2.1 | F(1,10) F = 2.8 | df:90 F = 52 |
||
| p: 0.407 | p: 0.0001 | p: 0.018 | p: 0.22 | p: 0.097 | p: 0.2281 | p: 0.1675 | p: 0.206 | p: 0.1729 | p: 0.127 | p: 0.035 # | ||
| (mmHg) | Control | 49 ± 6 (n = 6) | 49 ± 6 (n = 6) | 87 ± 15 (n = 6) | 72 ± 16 (n = 6) | 54 ± 22 (n = 6) | 43 ± 17 (n = 6) | 42 ± 14 (n = 6) | 35 ± 11 (n = 6) | 38 ± 12 (n = 6) | 45 ± 15 (n = 6) | |
| HI | 54 ± 13 (n = 6) | 68 ± 16* (n = 6) | 116 ± 30 (n = 6) | 79 ± 23 (n = 6) | 65 ± 19 (n = 6) | 68 ± 15* (n = 6) | 60 ± 29 (n = 6) | 50 ± 16 (n = 6) | 49 ± 8 (n = 6) | 60 ± 19 (n = 6) | ||
| F(1,10) F = 0.7 | F(1,10) F = 6.8 | F(1,10) F = 4.7 | F(1,10) F = 0.4 | F(1,10) F = 8.2 | F(1,10) F = 7.2 | F(1,10) F = 1.8 | F(1,10) F = 3.8 | F(1,10) F = 2.9 | F(1,10) F = 2.22 | df:90 F = 9.8 |
||
| p: 0.446 | p: 0.03 | p: 0.055 | p: 0.54 | p: 0.386 | p: 0.02 | p: 0.1995 | p: 0.0814 | p: 0.118 | p: 0.166 | p: 0.32 | ||
| (mmHg) | Control | 25 ± 6 (n = 6) | 27 ± 5 (n = 6) | 32 ± 11 (n = 6) | 38 ± 10 (n = 5) | 72 ± 45 (n = 6) | 92 ± 32 (n = 6) | 47 ± 20 (n = 6) | 80 ± 22 (n = 6) | 95 ± 50 (n = 6) | 58 ± 20 (n = 6) | |
| HI | 23 ± 6 (n = 6) | 18 ± 5* (n = 6) | 25 ± 8 (n = 6) | 38 ± 15 (n = 5) | 42 ± 20 (n = 6) | 47 ± 32* (n = 6) | 65 ± 18 (n = 6) | 41 ± 21* (n = 6) | 35 ± 11* (n = 6) | 24 ± 7* (n = 6) | ||
| F(1,10) F = 1.32 | F(1,10) F = 8.5 | F(1,10) F = 1.0.3 | F(1,8) F = 0.001 | F(1,10) F = 2.3 | F(1,10) F = 5.6 | F(1,10) F = 2.64 | F(1,10) F = 9.2 | F(1,10) F = 8.3 | F(1,10) F = 14.9 | df:72 F = 20 |
||
| p: 0.276 | p: 0.015 | p: 0.268 | p: 0.94 | p: 0.1597 | p: 0.04 | p: 0.1352 | p: 0.013 | p: 0.016 | p: 0.003 | p: 0.003 # | ||
| (mL/dL) | Control | 7 ± 3 (n = 6) | 7 ± 3 (n = 6) | 9 ± 4 (n = 6) | 11 ± 4 (n = 5) | 14 ± 3 (n = 6) | 15 ± 3 (n = 6) | 14 ± 3 (n = 6) | 15 ± 3 (n = 6) | 14 ± 3 (n = 6) | 13 ± 3 (n = 6) | |
| HI | 6 ± 3 (n = 6) | 4 ± 2* (n = 6) | 7 ± 4 (n = 6) | 12 ± 4 (n = 5) | 11 ± 4 (n = 6) | 11 ± 4 (n = 6) | 12 ± 4 (n = 6) | 10 ± 5 (n = 6) | 10 ± 5* (n = 6) | 6 ± 3* (n = 6) | ||
| F(1,10) F = 0.49 | F(1,10) F = 5.1 | F(1,10) F = 0.5 | F(1,8) F = 0.3 | F(1,10) F = 1.8 | F(1,10) F = 3.0 | F(1,10) F = 0.78 | F(1,10) F = 3.9 | F(1,10) F = 5.9 | F(1,10) F = 14 | df:72 F = 20 |
||
| p: 0.50 | p: 0.05 | p: 0.47 | p: 0.6 | p: 0.21 | p: 0.112 | p: 0.4 | p: 0.077 | p: 0.035 | p: 0.004 | p: 0.01 # | ||
| (mL/min) | Control | 2.5 ± 1.7 (n = 6) | 2.3 ± 1.2 (n = 6) | 4.5 ± 2.6 (n = 6) | 5 ± 2 (n = 5) | 4.5 ± 1.8 (n = 6) | 3.8 ± 1.0 (n = 6) | 2.9 ± 0.9 (n = 6) | 3.7 ± 1.1 (n = 6) | 4.0 ± 1.6 (n = 6) | 3.7 ± 1.1 (n = 6) | |
| HI | 2.3 ± 1.8 (n = 6) | 2.0 ± 1.7 (n = 6) | 3.2 ± 3.5 (n = 6) | 3 ± 1 (n = 5) | 4.3 ± 2.7 | 4.1 ± 2.2 (n = 6) | 4.6 ± 2.3 (n = 6) | 3.7 ± 2.2 (n = 6) | 3.3 ± 1.7 (n = 6) | 1.9 ± 1.2 * (n = 6) | ||
| F(1,10) F = 0.02 | F(1,10) F = 0.09 | F(1,10) F = 0.57 | F(1,8) F = 5.4 | F(1,10) F = 0.04 | F(1,10) F = 0.12 | F(1,10) F = 3 | F(1,10) F = 0.1 | F(1,10) F = 0.46 | F(1,10) F = 7.2 | df:72 F = 2.4 |
||
| p: 0.9 | p: 0.77 | p: 0.47 | p: 0.055 | p: 0.84 | p: 0.74 | p: 0.1132 | p: 0.94 | p: 0.52 | p: 0.023 | p: 0.33 | ||
| OD (mL/min) | Control | 4.8 ± 3 (n = 6) | 4.4 ± 2.3 (n = 6) | 10.2 ± 5.5 (n = 6) | 9.3 ± 2.1 (n = 5) | 8.3 ± 5.3 (n = 6) | 6.8 ± 3.0 (n = 6) | 7.3 ± 5.5 (n = 6) | 8.6 ± 6.3 (n = 6) | 8.1 ± 5.5 (n = 6) | 8.0 ± 3.0 (n = 6) | |
| HI | 5.0 ± 3.3 (n = 6) | 5.3 ± 2.8 (n = 6) | 8.8 ± 7.2 (n = 6) | 7.9 ± 4.2 (n = 5) | 9.2 ± 6.9 (n = 6) | 8.6 ± 3.9 (n = 6) | 9.5 ± 5.2 (n = 6) | 7.6 ± 4.6 (n = 6) | 6.7 ± 3.5 (n = 6) | 4.2 ± 2.3* (n = 6) | ||
| F(1,10) F = 0.28 | F(1,10) F = 0.32 | F(1,10) F = 0.14 | F(1,8) F = 0.72 | F(1,10) F = 0.07 | F(1,10) F = 0.8 | F(1,10) F = 0.55 | F(1,10) F = 0.08 | F(1,10) F = 0.29 | F(1,10) F = 5.9 | df:72 F = 2.36 |
||
| p: 0.61 | p: 0.59 | p: 0.72 | p: 0.42 | p: 0.8 | p: 0.39 | p: 0.47 | p: 0.78 | p: 0.60 | p: 0.0355 | p: 0.33 | ||
Data are expressed as mean ± SD. B, baseline fetal time point; HI, hypoxic–ischemic time point; V, time point of connection to a ventilator; , arterial oxygen content;
, cerebral oxygen consumption; OD, oxygen delivery. *p < 0.05 vs. control group (one-way ANOVA). #p < 0.05 control group vs. hypoxic–ischemic groups (two-way ANOVA for repeated measures). For pH and parameters six subjects per group along the 10 time points were considered. For , , and OD, five subject per group along the 10 time points were considered due to in the 15 min of postnatal life two values (one in each group) were lost during gas analyze.