Figure 7.—

The maximum frequency attained by sterile mutations, %_max. (A) The distribution of %_max across the four regimes shows that sterile trajectories attained greater frequency in smaller populations and when sterile mutations confer a larger selective advantage. (B) There is a strong positive correlation between s_up and %_max (P < 10⁻⁵, Spearman's rank correlation on the combined data). The black line is the best-fit linear regression (Pearson's) to the data. Separating the data from RM and BY lines still produces a significant positive correlation (P = 0.0008 and P < 10⁻⁵ for s_ste = 0.6% and 1.5%, respectively, Spearman's rank correlation). However, the best-fit line to the s_ste = 1.5% data is shifted to a higher %_max relative to the best-fit line to the s_ste = 0.6% data. Sterile mutations with a higher fitness advantage, therefore, attain a higher %_max.