Table 3.

Animal Model Studies Have Demonstrated Histologic and Functional Damage

Shock Wave Lithotripsy
Animal Models
Histological Damage	Functional Damage
Parenchyma	Renal plasma flow
Nephron	Glomerular filtration rate
Vasculature	Serum creatinine
Histology
Acute Changes	Chronic Changes
Parenchymal hemorrhage	Nephron loss
Damage to small veins and arteries	Cortical fibrosis
Glomerular and peritubular capillaries	Medullary fibrosis
Cellular and tubular necrosis