Figure 2.

Activation maps (significance threshold at p<0.001 uncorrected for displaying purposes) showing significant main effects of memory found during memory formation and memory retrieval are shown. Note that all results shown in this and the subsequent figures were family-wise error rate-corrected for multiple comparisons at the cluster level across the entire brain (p<0.05), or the search volume of interests (amygdala, hippocampus), using a small volume correction (p<0.05). (a) On the left panel, activation maps from the whole-brain analysis during encoding are superimposed on a standard T1 image provided with MRIcron, showing significantly larger activations related to successful vs unsuccessful memory formation in the bilateral amygdala. (b) Whole-brain analysis during encoding further revealed that successful memory formation was associated with significant activity in the bilateral inferior frontal regions, shown superimposed on a rendered brain provided with SPM5. (c) The results from the ROI analysis during retrieval are shown. Greater activity for recognized as compared with forgotten stimuli is shown in the bilateral amygdala/hippocampus, superimposed on a standard T1 image provided with MRIcron. (d) Significant recognition effect in the right middle cingulate cortex is shown.