Figure 11.

Effect of early post-stressor intervention with PDTC on behavioral stress responses. A single exposure to PSS followed by immediate administration of PDTC significantly increased the time spent in the open arms (a), the number of entries to the open arms (b), and decreased anxiety index (d) when compared with vehicle treatment. PDTC administration reduced the response to the stimulus (startle amplitude) (e) and reversed the stress-induced habituation (f) deficit found in vehicle-treated rats, exposure–treatment interaction. Early treatment with TDTC reduced the prevalence of PTSD-like behavioral responses (EBR) (g) relative to vehicle control treatment. No differences were observed in the prevalence of minimal behavioral responders (h) or partial behavioral responses (i). All data represent group mean±SEM.