Figure 2.

Systemic mGlu2/3 receptor activation by the selective agonist, LY379268, blunts the discriminative stimulus properties of alcohol. (a) Examination of mGlu2/3 receptor modulation of the discriminative stimulus effects of alcohol showed significant decreases in alcohol-appropriate responding after treatment with LY379268 (1 and 3 mg/kg, i.p.; n=10) at a cumulative alcohol dose of 1 g/kg. Note: 7 of the 10 rats responded when given a combination of the highest dose of alcohol (1.7 g/kg) and the highest dose of LY379268 (3 mg/kg). (b) Response rate was not significantly decreased by LY379268. These data suggest that activity at mGlu2/3 receptors has a role in modulating the discriminative stimulus properties of alcohol. Horizontal dashed lines (>80%) lines denote full substitution for the discriminative stimulus effects of alcohol. Graphed values are expressed as mean±SEM. ^*p<0.05 vs vehicle (Tukey post hoc).