Figure 1.

Dose-dependent effect of KYNA on extracellular levels of glutamate in the hippocampus. After 2 h of baseline collection, KYNA was applied intra-hippocampally for 2 h by reverse dialysis (bar). Data are expressed as a percentage of baseline (see Results for absolute value) and are the mean±SEM (n=5 per group). ^# and ^*P<0.05 vs baseline for 100 and 300 nM KYNA, respectively (two-way ANOVA with Bonferroni's post-hoc test).