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. 2011 Jul 27;36(11):2357–2367. doi: 10.1038/npp.2011.127

Figure 2.

Figure 2

Dose-dependent effects of ESBA on extracellular KYNA and glutamate levels in the hippocampus. After 2 h of baseline collection, ESBA was applied intra-hippocampally for 2 h by reverse dialysis (bar). KYNA (a) and glutamate (b) were measured in the same dialysate. Data are expressed as a percentage of baseline values and are the mean±SEM (n=4 per group). # and *P<0.05 vs baseline for 1 and 3 mM ESBA, respectively (two-way ANOVA with Bonferroni's post-hoc test). (c) After 2 h of baseline collection, ESBA (1 mM) and KYNA (100 nM) were co-infused into the hippocampus for 2 h (bar). Data are expressed as a percentage of baseline values and are the mean±SEM (n=5). Perfusion with ESBA+KYNA did not affect extracellular glutamate levels (P>0.05; two-way ANOVA with Bonferroni's post-hoc test). Absolute baseline values of KYNA and glutamate are given under Results.