Figure 3.

Acute, unilateral i.c.v. infusion of kynurenine or ESBA affects neurochemistry in the contralateral hippocampus. After 2 h of baseline collection, test compounds were applied i.c.v. (a) kynurenine (1 mM); (b) ESBA (10 mM); (c) ESBA (10 mM)+KYNA (10 μM)) (arrows) and the microdialysate was collected from the contralateral hippocampus. KYNA and glutamate were measured in the same dialysate where applicable. Data are expressed as a percentage of baseline (see Results for absolute values) and are the mean±SEM (n=4 for kynurenine; n=5 for ESBA; n=5 for ESBA+KYNA). ^# and ^*P<0.05 vs the respective baseline (two-way ANOVA with Bonferroni's post-hoc test).