Table 1.

Histological score of both ischemic-reperfused (TI/R) and contralateral testes, at 24 h

Experimental groups	Extratubular edema	Venular ectasia	Lobular coagulative necrosis
Ischemic and reperfused testis
Sham + vehicle	0	0	0
Sham + NDP-α-MSH	0	0	0
TI/R + vehicle	1.8 ± 0.5a	2.3 ± 0.8a	0.4 ± 0.5a
TI/R + NDP-α-MSH	0.8 ± 0.4b	1.1 ± 0.5b	0.3 ± 0.5
VGX + TI/R + vehicle	1.7 ± 0.8	1.9 ± 0.9	0.4 ± 0.8
VGX + TI/R + NDP-α-MSH	1.6 ± 0.5c	2.0 ± 0.6c	0.7 ± 0.5
Chlorisondamine + TI/R + NDP-α-MSH	1.9 ± 0.6c	2.0 ± 0.8c	0.4 ± 0.8
HS024 + TI/R + NDP-α-MSH	2.0 ± 0.6c	2.3 ± 0.5c	0.4 ± 0.5
Contralateral testis
Sham + vehicle	0	0	0
Sham + NDP-α-MSH	0	0	0
TI/R + vehicle	1.1 ± 0.5a	1.6 ± 0.7a	0.2 ± 0.1a
TI/R + NDP-α-MSH	0.5 ± 0.4b	0.8 ± 0.4b	0.09 ± 0.04
VGX + TI/R + vehicle	1.2 ± 0.5	1.5 ± 0.6	0.1 ± 0.03
VGX + TI/R + NDP-α-MSH	1.3 ± 0.3c	1.7 ± 0.8c	0.4 ± 0.1c
Chlorisondamine + TI/R + NDP-α-MSH	1.3 ± 0.6c	1.6 ± 0.8c	0.2 ± 0.09c
HS024 + TI/R + NDP-α-MSH	1.6 ± 0.6c	1.8 ± 0.5c	0.2 ± 0.07c

Each group included seven animals. Histologic grading was based on the following scale: 0 (absent), 1 (mild), 2 (moderate), and 3 (severe). VGX, Vagotomy. Data are presented as means ± sd.

^aP < 0.005 vs. sham + vehicle.

^bP < 0.005 vs. TI/R + vehicle.

^cP < 0.005 vs. TI/R + NDP-α-MSH.