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Cartoon of glucose-lowering drug discovery. Although several new classes of glucose-lowering agents have become available in the past several years, the prevalence of the root cause of type 2 diabetes, namely obesity (the elephant in the room when any new hypoglycemic agents are being developed), has continued to increase unabated, and use of some diabetes medications actually results in increased body weight (exogenous insulin, sulfonylureas, PPAR-γ agonists).
