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. Author manuscript; available in PMC: 2012 Sep 16.
Published in final edited form as: Mol Cell. 2011 Sep 16;43(6):982–992. doi: 10.1016/j.molcel.2011.07.025

Figure 7. Model of HVS miRNA biogenesis pathway.

Figure 7

The Integrator complex recognizes the 3′ box and Int11 co-transcriptionally cleaves the HSUR-miRNA primary transcript. The released pre-snRNA molecule exits the nucleus for further processing, while the viral pre-miRNA undergoes export directed by Exportin-5 (XPO5) to the cytoplasm, where it is recognized and processed by Dicer to yield two mature Ago-associated HVS miRNAs.