Table 6.
Limited vs diffuse SSc
| Variable | Limited SSc | Diffuse SSc | P value |
|---|---|---|---|
| Patient no. | 8 | 9 | ---- |
| % Female | 75% | 89% | 0.25 |
| Age, years | 57.38 ± 3.13 (40–66) | 53.11 ± 2.57 (42–62) | 0.31 |
| TSS (0–51) | 7 ± 0.59 (5–9) | 13 ± 1.97 (3–21) | <0.02 |
| MSS-Skin (0–4) | 1.0 (0–1) | 1.44 ± 0.18 (1–2) | 0.03 |
| MSS-Gen | 0.38 ± 0.2 (0–1) | 0.67 ± 0.37 (0–3) | 0.25 |
| MSS-GI | 1.3 ± 0.29 (0–3) | 1. 56 ± 0.29 (0–3) | 0.16 |
| GMA, ch 1 Ar | 25.7 ± 5.77 (0–46.2) | 7.52 ± 3.26 (0–28.6) | 0.02 |
| GIDQ, Certain (%) | 87.3 ± 6.4 (50–100) | 44.4 ± 10.3 (0–100) | <0.01 |
| Coping | 89 ± 3.27 (80–100) | 55.55 ± 9.5 (0–84) | <0.01 |
| Work limitation | 5.75 ± 3.03 (0–22) | 45.44 ± 14.05 (0–100) | 0.02 |
| Social limitation | 10.63 ± 4.11 (0–32) | 48.22 ± 8.2 (10–100) | <0.01 |
| Disease rating | 41 ± 9.23 (0–78) | 46.22 ± 5.09 (20–80) | 0.63 |
| SF-36: Social fcn | 51.03 ± 1.9 (46–57) | 36.03 ± 3.22 (19–46) | <0.01 |
| Mental Health | 52.43 ± 2.66 (39–64) | 41.10 ± 4.4 (18–64) | 0.02 |
| Plasma VIP (ng mL−1) | 23.8 ± 0.1 (18.7–26.2) | 21.23 ± 1.8 (15.66–26) | 0.11 |
| Plasma motilin (pg mL−1) | 19 ± 2.38 (13–25) | 30.44 ± 6 (16–60) | 0.11 |
Analysis between groups of limited compared to diffuse cutaneous systemic sclerosis (SSc) by Student’s t-test. Data are presented as percentages or as mean + SEM and (range of values). TSS: total skin score: (0–51). MSS: Skin, modified Medsger Severity Scale-Skin component; MSS-Gen: modified Medsger Severity Scale-General; MSS-GI: modified Medsger Severity Scale-GI tract; GMA: gastric myoelectrical activity, % gastric arrhythmia, channel 1. Gastrointestinal Dysmotility Questionnaire (GIDQ) quality of life questions. (36) How certain are you that you can manage your GI symptoms so that you can do the things you enjoy doing? (45) How effectively are you coping with your GI problems? (46). Have your GI problems limited your work at your place of employment? (47) Has your GI problems limited your social life? (48) Overall, considering pain, discomfort, limitations in your daily life and other changes in your body and life; how severe would you rate your disease today?’. Social fcn: Social functioning and Mental Health domains, Plasma VIP levels, vasoactive intestinal peptide, in ng mL−1, and plasma motilin levels, in pg mL−1.