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. 2011 Sep 20;6(9):e24399. doi: 10.1371/journal.pone.0024399

Figure 1. YKL-40 levels in human and murine CF lung disease.

Figure 1

A. YKL-40 levels in CF patients and healthy controls YKL-40 protein levels were quantified by means of ELISA in sera and sputum supernatants from cystic fibrosis (CF) or healthy control subjects. The left graph depicts means ± SDs, the right scatter graph depicts individual patients with horizontal bars as medians; *P<0.05 ** P<0.01 disease group compared to the control group. Horizontal bars indicate comparisons among the disease groups. B. BRP-39 levels in murine CF-like lung disease. BRP-39 protein levels were quantified by means of ELISA in BAL fluids from βENaC-Tg (n = 9) and WT mice (n = 7). *P<0.05; C. YKL-40/BRP-39 airway levels and lung function in human and murine CF lung disease. Left panel: YKL-40 protein levels were quantified by means of ELISA in sputum supernatants from CF patients (n = 59). FEV1: Forced expiratory volume in 1 second (% of predicted). Right panel: BRP-39 protein levels were quantified by means of ELISA in BAL fluids from βENaC-Tg (n = 9, grey fill) and WT mice (n = 7, white fill).