Table 2. Association test results for YKL-40 SNPs.
SNP | Position | Location | Alleles | MAF FEV1% @20 yrs≤70 | MAF FEV1% @20 yrs>70 | OR* | Pvalue |
rs871799 | −14,120 | Promoter | C/G | 0.113 | 0.192 | 0.24 | 0.043 |
rs2153101 | −12,723 | Promoter | T/A | 0.215 | 0.189 | 1.31 | 0.711 |
rs946263 | −9,630 | Promoter | A/G | 0.144 | 0.138 | 0.73 | 1.000 |
rs4950929 | −4,374 | Promoter | T/G | 0.215 | 0.200 | 0.82 | 1.000 |
rs6691378 | −1,371 | Promoter | G/A | 0.136 | 0.154 | 1.78 | 0.469 |
rs10399805 | −247 | Promoter | G/A | 0.156 | 0.178 | 1.11 | 1.000 |
rs4950928 | −131 | Promoter | C/G | 0.226 | 0.183 | 1.09 | 1.000 |
rs1538372 | +1,220 | Intron 2 | G/A | 0.371 | 0.337 | 0.94 | 1.000 |
rs880633 | +2,951 | Exon 5 | T/C | 0.419 | 0.522 | 0.46 | 0.016 |
rs2275352 | +5,573 | Intron 7 | G/A | 0.188 | 0.154 | 0.71 | 1.000 |
*recessive model; MAF, minor allele frequency; FEV1%@20 yrs, age-adjusted (at 20 years) longitudinal forced expiratory volume (FEV1) (19); OR, odds ratio.