Table 1. Spearman's correlations using alternative recombination rate datasets.
Variable | Statistic | Overall genic | Weighted mean | Base pair median | Interval mean | Interval median | Mean smoothed1 | Median smoothed1 | Mean smoothed2 | Median smoothed2 | ||
X | Y | Z | ||||||||||
K i | GC | RRSA | ρ | −0.081 | −0.081 | −0.081 | −0.081 | −0.081 | −0.089 | −0.083 | −0.092 | −0.081 |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRM | ρ | −0.08 | −0.079 | −0.079 | −0.079 | −0.079 | −0.085 | −0.079 | −0.088 | −0.077 | ||
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRF | ρ | −0.08 | −0.08 | −0.08 | −0.08 | −0.08 | −0.081 | −0.079 | −0.083 | −0.078 | ||
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RT | RRSA | ρ | −0.08 | −0.08 | −0.081 | −0.08 | −0.08 | −0.086 | −0.079 | −0.087 | −0.077 | |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRM | ρ | −0.081 | −0.081 | −0.081 | −0.081 | −0.081 | −0.089 | −0.082 | −0.09 | −0.082 | ||
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRF | ρ | −0.078 | −0.078 | −0.079 | −0.078 | −0.079 | −0.076 | −0.078 | −0.076 | −0.077 | ||
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRSA | - | ρ | 0.045 | 0.041 | 0.038 | 0.045 | 0.043 | 0.095 | 0.084 | 0.1 | 0.088 | |
P | 0.007 | 0.015 | 0.023 | 0.007 | 0.01 | 1.24×10−8 | 5.14×10−7 | 2.39×10−9 | 1.67×10−7 | |||
RRM | - | ρ | 0.015 | 0.01 | 0.006 | 0.013 | 0.009 | 0.057 | 0.054 | 0.058 | 0.057 | |
P | 0.379 | 0.544 | 0.73 | 0.454 | 0.574 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRF | - | ρ | 0.044 | 0.041 | 0.039 | 0.044 | 0.043 | 0.084 | 0.071 | 0.092 | 0.08 | |
P | 0.009 | 0.015 | 0.02 | 0.008 | 0.01 | 5.22×10−7 | 2.62×10−5 | 4.25×10−8 | 1.81×10−6 | |||
RRSA | GC | ρ | 0.051 | 0.047 | 0.044 | 0.05 | 0.049 | 0.104 | 0.088 | 0.111 | 0.09 | |
P | 0.002 | 0.003 | 0.003 | 0.001 | 0.005 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRM | GC | ρ | 0.021 | 0.016 | 0.013 | 0.019 | 0.016 | 0.067 | 0.055 | 0.07 | 0.056 | |
P | 0.114 | 0.178 | 0.234 | 0.137 | 0.157 | 0.001 | 0.003 | 0.001 | 0.001 | |||
RRF | GC | ρ | 0.047 | 0.044 | 0.043 | 0.047 | 0.046 | 0.087 | 0.071 | 0.096 | 0.08 | |
P | 0.004 | 0.005 | 0.005 | 0.002 | 0.004 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRSA | RT | ρ | 0.042 | 0.039 | 0.037 | 0.043 | 0.041 | 0.1 | 0.082 | 0.105 | 0.084 | |
P | 0.008 | 0.01 | 0.012 | 0.005 | 0.014 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRM | RT | ρ | 0.017 | 0.012 | 0.01 | 0.015 | 0.012 | 0.068 | 0.055 | 0.07 | 0.058 | |
P | 0.162 | 0.209 | 0.3 | 0.197 | 0.213 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRF | RT | ρ | 0.038 | 0.035 | 0.035 | 0.039 | 0.038 | 0.08 | 0.067 | 0.088 | 0.076 | |
P | 0.013 | 0.015 | 0.022 | 0.013 | 0.015 | 0.001 | 0.001 | 0.001 | 0.001 | |||
GC | RT | RRSA | ρ | 0.296 | 0.295 | 0.294 | 0.295 | 0.295 | 0.29 | 0.294 | 0.289 | 0.294 |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRM | ρ | 0.292 | 0.291 | 0.29 | 0.292 | 0.291 | 0.283 | 0.293 | 0.278 | 0.293 | ||
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRF | ρ | 0.296 | 0.296 | 0.295 | 0.296 | 0.296 | 0.295 | 0.293 | 0.296 | 0.293 | ||
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | |||
RRSA | - | ρ | 0.067 | 0.068 | 0.077 | 0.067 | 0.07 | 0.102 | 0.048 | 0.126 | 0.031 | |
P | 6.44×10−5 | 4.80×10−5 | 4.51×10−6 | 6.46×10−5 | 2.76×10−5 | 1.07×10−9 | 0.004 | 4.45×10−14 | 0.064 | |||
RRM | - | ρ | 0.078 | 0.078 | 0.085 | 0.078 | 0.081 | 0.111 | 0.01 | 0.144 | −0.016 | |
P | 3.33×10−6 | 3.19×10−6 | 3.85×10−7 | 3.79×10−6 | 1.39×10−6 | 3.39×10−11 | 0.539 | 0 | 0.343 | |||
RRF | - | ρ | 0.038 | 0.037 | 0.048 | 0.035 | 0.041 | 0.027 | 0.005 | 0.044 | −0.007 | |
P | 0.025 | 0.026 | 0.005 | 0.036 | 0.015 | 0.104 | 0.753 | 0.008 | 0.692 | |||
RRSA | RT | ρ | 0.081 | 0.08 | 0.083 | 0.079 | 0.08 | 0.092 | 0.057 | 0.116 | 0.046 | |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.005 | |||
RRM | RT | ρ | 0.074 | 0.073 | 0.074 | 0.073 | 0.074 | 0.079 | 0.008 | 0.109 | −0.02 | |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.318 | 0.001 | 0.116 | |||
RRF | RT | ρ | 0.063 | 0.061 | 0.064 | 0.059 | 0.061 | 0.048 | 0.021 | 0.064 | 0.011 | |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.007 | 0.104 | 0.001 | 0.252 | |||
RT | RRSA | - | ρ | −0.034 | −0.027 | −0.009 | −0.03 | −0.022 | 0.048 | −0.024 | 0.051 | −0.045 |
P | 0.041 | 0.102 | 0.578 | 0.074 | 0.188 | 0.005 | 0.148 | 0.002 | 0.008 | |||
RRM | - | ρ | 0.025 | 0.028 | 0.049 | 0.026 | 0.034 | 0.122 | 0.01 | 0.138 | 0.01 | |
P | 0.135 | 0.095 | 0.004 | 0.122 | 0.041 | 2.6×10−13 | 0.56 | 1.2×10−16 | 0.547 | |||
RRF | - | ρ | −0.076 | −0.07 | −0.046 | −0.073 | −0.061 | −0.062 | −0.051 | −0.056 | −0.059 | |
P | 6.34×10−6 | 3.19×10−5 | 0.006 | 1.37×10−5 | 0 | 0 | 0.003 | 0.001 | 0 | |||
RRSA | GC | ρ | −0.056 | −0.05 | −0.033 | −0.052 | −0.045 | 0.019 | −0.04 | 0.015 | −0.056 | |
P | 0.001 | 0.003 | 0.02 | 0.001 | 0.005 | 0.14 | 0.009 | 0.189 | 0.001 | |||
RRM | GC | ρ | 0.002 | 0.005 | 0.025 | 0.003 | 0.011 | 0.095 | 0.007 | 0.102 | 0.015 | |
P | 0.443 | 0.376 | 0.067 | 0.423 | 0.255 | 0.001 | 0.349 | 0.001 | 0.171 | |||
RRF | GC | ρ | −0.091 | −0.084 | −0.063 | −0.087 | −0.076 | −0.073 | −0.054 | −0.072 | −0.06 | |
P | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 | 0.001 |
Spearman's correlations at the genic level for each alternative method used to curate genic recombination rate data where: Z = the controlling variable used in partial Spearman's correlations between variables X and Y; K i = intronic substitution rate between mouse and rat; RT = median replication time for each gene; GC = repeat-masked intronic G+C content for each gene; RRSA, RRM and RRF = sex-averaged, male and female genic recombination rates respectively.