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. 2011 Sep 20;6(9):e25007. doi: 10.1371/journal.pone.0025007

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Bian et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A, B) The specific recognition mode is conserved in Gal-3-TFN or Gal-3-GM1 complex. (C) Consensus binding mode between galectins and TF antigen, which is unique in a water molecule mediated hydrogen bond network. (D) Sequence alignment of carbohydrate recognition domain for human galectins. The critical residues for the binding mode highlighted in triangles are conservative.