TABLE 1.

Heritability of transcript levels for 57 genes implicated in pathways of Th1 and Th2 immune response: maximum likelihood estimates and associated P-values.

Transcript	h2	P-value	Transcript	h2	P-value
CCR3	0.138	4.26 × 10-3	IL2RB	0.213	1.20 × 10-4
CD28	0.251	7.50 × 10-6	IL4R	0.243	1.36 × 10-4
CD3D	0.278	4.72 × 10-4	IL10	0.125	7.28 × 10-3
CD3E	0.152	1.66 × 10-2	IL10RB	0.166	3.25 × 10-3
CD3G	0.388	5.73 × 10-11	IL12B/IL12p40	0.120	4.76 × 10-2
CD4	0.303	3.00 × 10-5	IL12RB1	0.392	1.37 × 10-13
CD69	0.223	1.92 × 10-3	IL15	0.092	1.30 × 10-2
CD86	0.247	8.00 × 10-7	IL18	0.179	5.60 × 10-3
CMIP	0.388	1.87 × 10-10	IRF1	0.291	1.00 × 10-7
CSF2RB	0.380	2.88 × 10-10	ITGB2	0.291	1.47 × 10-8
CTLA4	0.623	2.29 × 10-16	KLRD1	0.261	2.80 × 10-6
FYN	0.335	4.80 × 10-9	LAG3	0.214	3.98 × 10-5
GRB2	0.288	4.02 × 10-9	LAT	0.143	7.76 × 10-3
HLA-DMA	0.322	1.00 × 10-7	LTA/TNFB	0.345	3.01 × 10-11
HLA-DMB	0.353	1.60 × 10-6	LTB (isoform b)	0.291	4.00 × 10-7
HLA-DOB	0.384	3.53 × 10-8	NFATC1	0.283	1.00 × 10-7
HLA-DPA1	0.265	8.97 × 10-5	NFATC3	0.239	2.00 × 10-7
HLA-DPB1	0.276	3.50 × 10-4	NFKB1	0.418	4.77 × 10-11
HLA-DQA1	0.786	3.42 × 10-23	PTPN11/SHP2	0.129	5.02 × 10-3
HLA-DQA2	0.306	1.00 × 10-7	PTPN22	0.366	4.50 × 10-9
HLA-DQB1	0.508	9.10 × 10-14	STAT1	0.310	9.64 × 10-9
HLA-DRA	0.432	7.98 × 10-15	STAT6	0.210	6.06 × 10-5
HLA-DRB1	0.340	4.00 × 10-7	TNFRSF5/CD40	0.253	8.05 × 10-5
HLA-DRB3	0.335	8.79 × 10-5	TNFSF6/FASL	0.111	3.07 × 10-2
HLA-DRB4	0.283	2.68 × 10-5	TNFSF11/RANKL	0.206	9.35 × 10-5
HLA-DRB5	0.634	3.29 × 10-19	TRIM	0.228	1.16 × 10-4
ICOS	0.221	2.70 × 10-5	WSX1/IL27RA	0.094	2.89 × 10-2
IFNG	0.282	5.88 × 10-3	ZAP-70	0.221	4.33 × 10-5
IFNGR1	0.105	1.64 × 10-2