TABLE 2.

Results of linkage analyses describing significant evidence for 14 QTLs influencing expression levels for candidate genes implicated in pathways of Th1 and Th2 immune response. Gene names in bold indicate transcript levels for which the eQTL heritability appears to account for virtually all trait heritability. Abbreviations: eQTL – expression QTL; PHA – Papio hamadryas; HSA – Homo sapiens.

Transcript	LOD	Genome-wide P-value	eQTL heritability	PHA chromosome	HSA 1.5 LOD-drop region	HSA known location	Likely regulation
CSF2RB	2.82	0.04229	0.368	10	22q11.1-22q13.31	22q13.1	Cis
CTLA4	4.79	0.00342	0.406	12	2q32.3-2q36.1	2q33	Cis
FYN	3.46	0.00883	0.331	8	8p11.21-8q22.3	6q21	Trans
HLA-DMA	2.76	0.04898	0.228	18	18p11.22-18q21.32	6p21.3	Trans
HLA-DPA1	3.12	0.02029	0.276	15	9p21.1-9q32	6p21.3	Trans
HLA-DQA1	14.87	1.027 × 10-14	0.600	4	6p22.3-6p12.3	6p21.3	Cis
HLA-DRA	3.11	0.02079	0.314	4	6p12.1-6q24.3	6p21.3	Trans
HLA-DRB1	6.35	7.677 × 10-6	0.382	4	6p22.3-6p12.3	6p21.3	Cis
HLA-DRB3	10.06	9.692 × 10-10	0.399	4	6p22.3-6q12	6p21.3	Cis
HLA-DRB4	5.53	0.00005	0.339	4	6p24.1-6q12	6p21.3	Cis
HLA-DRB5	8.10	1.102 × 10-7	0.475	4	6p22.3-6q11.1	6p21.3	Cis
ITGB2	3.65	0.00555	0.316	10	22q12.3-22q13.2	21q22.3	Trans
NFATC3	3.58	0.00658	0.266	10	22q11.23-22q13.31	16q22.2	Trans
STAT6	4.19	0.00148	0.252	11	12p13.1-12q23.2	12q13	Cis