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. 2011 Sep 20;6(9):e25059. doi: 10.1371/journal.pone.0025059

Figure 2. Steps of HM on HH analysis.

Figure 2

HM on HH analysis is composed of 4 steps that are serially performed. (A) Homozygosity mapping (HM). The RHSs are determined for each patient, and the RHS overlaps are obtained. (B) Intermediate analysis 2 (IM2). The RHS overlap IGs are determined. (C) Intermediate analysis 3 (IM3). The RHS overlap IGs are compared. The RHS overlap IG is selected as a candidate region when the RHS overlap IG is the longest between the patients. (D) HH analysis using controls. RHS overlap IG-RCHH nests are compared. The RHS overlap IG is selected as a candidate region when the RHS overlap IG and the RCHH are both the longest between the patients.