Information Pertaining to the Mouse Models
(A) The mouse Y short arm (Yp; represented to scale in the magnified view) has seven single-copy genes, two duplicated genes, and one multi-copy gene. (Note that the mouse Y chromosome has a single distal pseudoautosomal region [PAR] on the long arm.)
(B) The Y chromosome short-arm-derived Sxra sex-reversal factor, here attached distal to the PAR on the X chromosome, includes most of the Yp genes.
(C) The Sxra-derived deletion variant Sxrb has a >900 kb deletion removing six single-copy genes (ΔSxr-b) and creating a Zfy2/1 fusion gene spanning the deletion breakpoint (†).
(D) H & E-stained stage XII-I testis tubule section from 30-day-old XSxraO and XESxrbO mice. In XSxraO there are many arrested, darkly stained (dying; stars), MI spermatocytes. In XESxrbO most of the MI spermatocytes have already divided to form interphasic secondary spermatocytes (arrow), and those that remain are lightly stained (healthy; arrowheads).
(E) Tables describing the transgenes and the mouse models analyzed in this study.
The scale bar for magnified views in (A), (B), and (C) represents 150 Kb; it represents 40 μm in (D).
See also Figure S1.