Figure 1.

Information Pertaining to the Mouse Models

(A) The mouse Y short arm (Yp; represented to scale in the magnified view) has seven single-copy genes, two duplicated genes, and one multi-copy gene. (Note that the mouse Y chromosome has a single distal pseudoautosomal region [PAR] on the long arm.)

(B) The Y chromosome short-arm-derived Sxr^a sex-reversal factor, here attached distal to the PAR on the X chromosome, includes most of the Yp genes.

(C) The Sxr^a-derived deletion variant Sxr^b has a >900 kb deletion removing six single-copy genes (Δ^Sxr-b) and creating a Zfy2/1 fusion gene spanning the deletion breakpoint (†).

(D) H & E-stained stage XII-I testis tubule section from 30-day-old XSxr^aO and X^ESxr^bO mice. In XSxr^aO there are many arrested, darkly stained (dying; stars), MI spermatocytes. In X^ESxr^bO most of the MI spermatocytes have already divided to form interphasic secondary spermatocytes (arrow), and those that remain are lightly stained (healthy; arrowheads).

(E) Tables describing the transgenes and the mouse models analyzed in this study.

The scale bar for magnified views in (A), (B), and (C) represents 150 Kb; it represents 40 μm in (D).

See also Figure S1.