Fig. 5.
Quantitative PCR results showing fold change of voltage-gated Na+ channel expression following noise exposure. (A) Graph showing voltage-gated Na+ channel mRNA expression from the modioli of control (clear bars, n = 6) noise exposed (filled bars, n = 7) animals shown as a percentage of β-actin expression. The expression level of NaV1.1 and NaV1.6 both significantly decreased (**, p < 0.01) following noise exposure while NaV1.7 RNA expression increased following noise exposure (**, p < 0.01) and mRNA for the other isoforms was not detected (n = 7). (B) Graph detailing the fold change of NaV1.1, NaV1.6 and NaV1.7 mRNA expression in the noise exposed animals. Each sample contained the mRNA isolated from a pair of modioli collected from one animal.