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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Clin Cancer Res. 2011 Aug 5;17(18):5953–5961. doi: 10.1158/1078-0432.CCR-11-1272

Figure 4.

Figure 4

Inhibitory effect of curcumin on inflammatory cytokines. Analysis of 14 salivary samples using the Human 9-Plex Ultrasensitive Electrochemiluminescent MULTI-SPOT Assay system followed by the cluster analysis shows decreased expression of all nine cytokines in A, supernatant and in B, cellular pellet. While the inhibition is variable as was seen in figure 3, cluster analysis points to enhanced inhibitory activity on tongue tumors indicating the usefulness of curcumin in the treatment of this tumor type. Overexpression of IL-6 and IL-8 observed in the supernatant samples of #11 and #13 confirmed the results obtained with the individual cytokine ELISA method (Figure 3 above), indicating the usefulness of either of the methods to detect interleukin expression in salivary samples.