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(a) Decoration of drug-loaded polymeric nanoparticle with GlcNAc should provide a mechanism whereby therapeutics may be delivered intracellularly to CMs. (b) The particle will be composed of the acid-labile poly(cyclohexane-1,4-diyl acetone dimethylene ketal) (PCADK). Once internalized, the particle will degrade into the biocompatible products acetone and cyclohexanedimethanol.
