Table 2.

Autophagy-related patents and putative applications in cardiovascular disease.

Patent category	Therapeutics/Target	Remarks	Patent Number	Ref
Autophagy induction	8-methylchroman-7-ol derivatives	Atherosclerosis, myocardial ischemia.	US2010173983	[98]
Proteinopathy treatment	Farnesyl transferase inhibitor	Myocardial ischemia, MI, vascular hyperplasia, cardiac hypertrophy, CHF, restenosis, atherosclerosis, hypertension, angina pectoris,	US2010160372	[97]
Autophagy regulation	Compounds that regulates ATG14L and Rubicon which binds Class III PI3K/Vps34- Beclin 1 complex,	Inflammatory cardiac diseases	WO2010030936	[96]
Autophagy induction	Glycosylated anti-tumor ether lipids (GAEL) are small molecules that induce and/or enhance autophagy in cells	Ischemic/reperfusion injury	WO2009092170	[95]
Autophagy regulation	Autophagy modulators identified by a high- throughput phenotypic screen	Reperfusion injury, ischemic cardiac disease	WO2008122038	[94]
Cardiac autophagy death regulation	siRNA against ANT isoforms which selectively regulates autophagic cell death	Treating cardiac ischemia	US20060210535	[93]
Autophagy regulation	A phosphorus-rapamycin analog, AP23573	Hyperproliferative vascular diseases (restenosis; graft vascular atherosclerosis; and cardiovascular disease, cerebral vascular disease, and peripheral vascular disease,	US20040073024	[90]
Anti-cardiac autophagic degeneration/death	Long-term administration of a colony-stimulating factor (G-CSF)	Ischemic cardiac failure, myocardial fibrosis, left ventricular remodeling	US2006051318	[92]
Cardiac atrophy	Agent that increases the expression of the runx1 gene to prevent or decrease cardiac autophagy	Treatment of a heart condition whereby heart muscle is destroyed	US2006003959	[91]