Table 3. Significant Differences in HFC Network Connectivity between the Mild AD Group at Baseline and the CN Group.
| Brain Region | Side | BA | Cluster Size (mm3) | Talairach Coordinates (LPI) | z-Score | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| Decreased connectivity in the positive HFC network | |||||||
| MOG | L | 28816 | -33 | -73 | 8.0 | -3.93 | |
| Fusiform gyrus | L | -24 | -55 | -10 | -2.88 | ||
| PCC | L | 30 | -4 | -67 | 10 | -3.14 | |
| Lingual gyrus | L | 18 | -6 | -69 | 5 | -2.81 | |
| Lingual gyrus | R | 18 | 6 | -75 | 2 | -2.73 | |
| Cuneus | L | 30 | -4 | -67 | 9 | -3.14 | |
| Cuneus | R | 18 | 14 | -81 | 27 | -3.25 | |
| SPC | L | 7 | 6032 | -7 | -65 | 58 | -2.93 |
| Precuneus | R | 7 | 5 | -52 | 52 | -2.87 | |
| Postcentral gyrus | R | 4 | 10 | -39 | 63 | -2.68 | |
| Decreased connectivity in the negative (anticorrelation) HFC network | |||||||
| DLPFC | R | 9 | 8776 | 27 | 39 | 36 | -3.76 |
| IFG | R | 13 | 41 | 23 | 11 | -2.90 | |
| ACC | R | 32 | 11 | 24 | 36 | -2.56 | |
The results were obtained with two sample t test, p < 0.05, cluster size > 4048 mm3, the whole brain corrected.
BA = Brodmann's area; LPI = left, posterior, and inferior; R = right; L = left; x, y, z = coordinates of peak locations in the Talairach space; HFC = hippocampal functional connectivity; MOG = middle occipital gyrus; PCC = posterior cingulate cortex; SPC = superior parietal cortex; DLPFC = dorsolateral prefrontal cortex; IFG = inferior frontal gyrus; ACC = anterior cingulate cortex.