Table 5. Cognitive Neural Correlates between Changes in Connectivity Strength in the HFC Network with ΔMMSE Scores and ΔADAS-cog Scores in Mild AD after Donepezil Treatment.
| Brain Region | Side | BA | Cluster Size (mm3) | Talairach Coordinates (LPI) | z-Score | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| ΔMMSE scores | |||||||
| Parahippocampus | L | 28 | 6576 | -27 | -13 | -28 | 3.99 |
| IFG | L | 9 | 5968 | -49 | 11 | 26 | -4.42 |
| Precentral gyrus | L | 6 | -47 | -2 | 26 | -3.29 | |
| Insula | L | 13 | -37 | -1 | 5 | -3.54 | |
| DLPFC | L | 9 | -46 | 6 | 37 | -2.37 | |
| ΔADAS-cog scores | |||||||
| DLPFC | L | 9 | 5544 | -38 | 39 | 30 | 2.73 |
| MFG | L | 6 | -13 | 10 | 50 | 2.90 | |
The results were obtained with linear regression analysis, p < 0.05, cluster size > 4048 mm3, the whole brain corrected.
BA = Brodmann's area; LPI = left, posterior, and inferior; R = right; L = left; x, y, z = coordinates of peak locations in the Talairach space; r = regression coefficient; MMSE = Mini-Mental State Examination; IFG, inferior frontal gyrus; DLPFC, dorsolateral prefrontal cortex; ADAS-cog = Alzheimer's Disease Assessment Scale-cognitive subscale; MFG = middle frontal cortex.