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. Author manuscript; available in PMC: 2012 Sep 26.
Published in final edited form as: Brain Res. 2011 Jul 28;1414:1–9. doi: 10.1016/j.brainres.2011.07.046

Figure 1. Central WIN55,212-2 dose-related hemodynamic changes in conscious rats.

Figure 1

Representative tracings and time course changes in mean arterial pressure (ΔMAP), heart rate (ΔHR) and percent change of plasma NE from baseline evoked by intracisternal WIN55,212-2 (WIN55; 3, 10 and 30 μg/rat) or its vehicle (veh) in conscious rats. On day 1, the vehicle and the 3 μg dose were administered and the 10 and 30 μg were administered on day 2. One h was allowed between consecutive WIN55,212-2 doses to permit BP and HR to return to baseline values. Arrow marks WIN55,212-2 injection. Values are mean ± S.E.M. (n=4 in each group). * or # P<0.05 significantly different compared to vehicle (veh) or low dose WIN55,212-2 (3 μg WIN55) values, respectively.