Fig. 2.

The effects of BL-6020/979 on food intake and energy expenditure are mediated by MC-4R. a and b Food intake and c and d relative oxygen consumption in wild-type (open bars) and MC-4R^−/− (black bars) mice in the first 4 h after application of 100 mg/kg BL-6020/979 p.o. or vehicle. e and f Body mass development in wild-type and MC-4R^−/− mice in the first 4 h after application of 100 mg/kg BL-6020/979 p.o. or vehicle. Note that data plotted for the resting (light; a, c, e) and active (dark; b, d, f) period were not measured during one 24-h interval and therefore not directly comparable. See text for more details