Table 1.

BL-6020/979 is orally bioavailable in mice, rats and dogs and penetrates the brain

	Mouse	Rat	Dog
Dose in mg/kg p.o.	50	50	10
Cplasma in nM	1269 ± 404	2277 ± 340	2426 ± 1036
Cbrain in nM	110 ± 26	151 ± 27	n.d.
b/p ratio in %	12	8	n.d.
PPB in %	92	87	93

BL-6020/979 was given orally at indicated dose. N = 3 per group, mean ± SD are given

b/p brain-to-plasma-ratio, n.d. not determined, PPB plasma protein binding