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Primary sequence alignment of the experimental GK structures from different organisms used for the construction of the closed homology model: 1S4Q for M. tuberculosis, 2AN9 from E. coli, 1LVG from M. musculus, and 2QOR from P. vivax. Conservation of the catalytic site is highlighted for residues bound to substrates via their side chain (and eventually backbone) and for residues bound to substrates only via their backbone. Amino-acid letters are shaded depending on residue type.
