Table 2.
A. At pH 3, as a function of temperature | ||||
---|---|---|---|---|
T (°C) | KA (M−1 × 10−3) | ΔGA (kcal mol−1) | ΔHA (kcal mol−1) | TΔSA (kcal mol−1) |
30 | 12.1 ± 0.2 | −5.7 | −3.4 ± 0.2 | 2.3 |
33 | 8.3 ± 0.5 | −5.5 | −5.8 ± 0.2 | −0.3 |
35 | 7.3 ± 0.4 | −5.5 | −7.4 ± 0.4 | −1.9 |
37 | 6.5 ± 0.3 | −5.4 | −9.6 ± 0.5 | −4.2 |
40 | 6.2 ± 0.4 | −5.4 | −14.8 ± 0.2 | −9.2 |
43 | 3.5 ± 0.7 | −5.1 | −23.6 ± 0.3 | −18.5 |
46 | 0.8 ± 0.1 | −4.3 | −34.2 ± 3.1 | −29.9 |
B. At 37°C, as a function of pH | ||||
pH | KA (M−1 × 10−3) | ΔGA (kcal mol−1) | ΔHA (kcal mol−1) | TΔSA (kcal mol−1) |
3.0 | 6.5 ± 0.3 | −5.4 | −9.6 ± 0.5 | −4.2 |
3.5 | 12.5 ± 1.6 | −5.8 | −2.7 ± 0.1 | 3.1 |
4.0 | 33.3 ± 0.9 | −6.4 | −1.9 ± 0.1 | 4.5 |
4.5 | 44.0 ± 1.7 | −6.6 | −0.9 ± 0.1 | 5.7 |