Table 3.

Western Blotting Results for FMRP, mGluR5, GABRβ3, GFAP, and β-Actin in Vermis

Adults	Control	Autistic	Change	P
FMRP/ β-actin	0.064 ± 0.031	0.016 ± 0.026	↓75%	0.038
mGluR5 Dimer/ β-actin	0.145 ± 0.144	0.092 ± 0.126	↓36%	ns
mGluR5 Total/ β-actin	0.183 ± 0.147	0.123 ± 0.138	↓33%	ns
mGluR5Dimer/mGluR5Total	0.945 ± 0.064	0.603 ± 0.327	↓36%	ns
GABRβ3 / β-actin	0.076 ± 0.029	0.048 ± 0.012	↓37%	0.050
GFAP/ β-actin	0.087 ± 0.084	0.928 ± 0.491	↑967%	0.029
β-actin	24.7 ± 3.17	22.9 ± 3.28	↓7.3%	ns
Age ± SD (years)	32.6 ± 7.89	35.7 ± 10.9	↑9.5%	ns
PMI ± SD (years)	21.5 ± 10.1	22.0 ± 8.91	↑2.3%	ns
Gender	3M:2F	7M:2F	--	--
Children	Control	Autistic	Change	P
FMRP/ β-actin	0.422 ± 0.166	0.295 ± 0.263	↓30%	ns
mGluR5 Dimer/ β-actin	0.099 ± 0.071	0.278 ± 0.077	↑181%	0.0084
mGluR5 Total/ β-actin	0.086 ± 0.064	0.286 ± 0.071	↑232%	0.0071
mGluR5Dimer/mGluR5Total	0.897 ± 0.058	0.972 ± 0.017	↑8.4%	0.049
GABRβ3 / β-actin	0.057 ± 0.038	0.075 ± 0.036	↑32%	ns
GFAP/ β-actin	0.156 ± 0.088	0.355 ± 0.101	↑128%	0.031
β-actin	21.64 ± 3.41	20.13 ± 5.15	↓7%	ns
Age ± SD (years)	10.7 ± 5.28	9.57 ± 4.28	↓11%	ns
PMI ± SD (years)	19.6 ± 8.45	21.7 ± 11.3	↑11%	ns
Gender	6M:0F	5M:2F	--	--

ns, not significant