Figure 5.

Cumulative score distributions computed for recurrent cancer mutations in the COSMIC database (release 49, September, 2010), the scores were computed for 10 005 unique non-synonymous point mutations affecting 3630 genes. Recurrent cancer mutations observed two or more times (1828) and highly recurrent mutations observed five or more times (712) are scoring significantly higher compared to mutations observed only once (8177); the ROC analysis (not shown) of separation of recurrent mutations from one-time-observed mutations gives AUC = 0.75; the accuracy of separation is ∼69%, when a percentage of false positives is equal to a percentage of false negatives.