Figure 7.

Cumulative score distributions computed for mutations in genes annotated as tumor suppressors and oncogenes in the COSMIC database; 4413 mutations in tumor suppressors and oncogenes are enriched in high-scoring mutations compared to 5592 mutations in genes non-annotated as TS and OG. The ROC analysis (not shown) of separation of recurrent mutations from one-time-observed mutations gives AUC = 0.6745; accuracy of separation is 64%, when the percentage of false positives is equal to the percentage of false negatives.