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. 2011 Jul 3;39(17):e118. doi: 10.1093/nar/gkr407

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Functional mutation in a predicted specificity position of RAC1 (Ras-related C3 botulinum toxin substrate 1). (A) The mutation affects a residue that is conserved as A (Ala) in subfamily #1 (top sequences, close homologues of RAC1) and as E (Glu) in subfamily #2 (bottom sequences, close homologues of CDC42); Uniprot name, species identifier, residues number range and subfamily number are in left columns. The sequence subfamilies and specificity scores (vertical bars at top) were computed from a non-redundant MSA (multiple sequence alignment) of 274 sequences using CEO clustering. The mutation A95E of RAC1 has a high specificity score in RAC1. (B) The position affected by the mutation is in the binding interface of RAC1 in contact with the T-lymphoma invasion and metastasis factor 1 (Tiam1); (PDB code 1foe).