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The glycosylase search model. (A) Glycosylases rotate around the DNA molecule interrogating bases (red) or by non-specific rotation when interrogation does not occur (blue). (B) A structural model of Fpg glycosylase undergoing slow diffusion, sampling for damage using a wedge amino acid (red) or fast diffusion without intrahelical interrogation (blue) (PDB 2F5O).
