Figure 1.

Phylogenetic tree of the human bromodomain family and substrate recognition of bromodomains. (a) Phylogenetic tree based on sequence alignments of predicted BRDs. For targets with multiple BRDs, the domains have been numbered starting from the N-terminus and the number is shown in parentheses. (b) Interaction of mouse BRD4 (Ref. 117) and mouse BRDT (Ref. 118) with monoacetylated Lys14 in histone H3 and a diacetylated H4 peptide monoacetylated on both Lys5 and Lys8. (c) Surface representation in similar orientation. See Table 1 for an explanation of protein symbols.