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. 2011 Oct;25(10):3436–3447. doi: 10.1096/fj.11-188300

Figure 5.

Figure 5.

Effects of CYP2C8 and ROS inhibition on LVDP recovery in Tie2-CYP2C8 Tr and WT hearts. A) LVDP recovery at R40 after treatment of WT and Tie2-CYP2C8 hearts with vehicle (0.05% DMSO) or trimethoprim (100 μM). B) LVDP recovery at R40 after treatment of WT and Tie2-CYP2C8 hearts with NAC (4 μM), or SOD (50 U/ml). C) Percentage infarct size and representative TIC stained images in WT and Tie2-CYP2C8 Tr hearts after treatment with NAC or SOD. Both NAC and SOD significantly increase LVDP recovery, reduce infarct size, and abolish the differences between WT and Tie2-CYP2C8 Tr hearts. Values are means ± se, n = 6–12/group. *P < 0.05 vs. WT; **P < 0.05 vs. untreated of same genotype; #P < 0.05 vs. Tie2-CYP2C8 Tr vehicle treated.