Table 1.
Cardiac parameters in WT and transgenic mice
| Parameter | WT | αMHC-CYP2J2 | Tie2-CYP2J2 | Tie2-CYP2C8 | Tie2-sEH |
|---|---|---|---|---|---|
| n | 53 | 11 | 17 | 23 | 11 |
| Heart rate (beats/min) | 352 ± 7 | 366 ± 11 | 372 ± 9 | 378 ± 10 | 345 ± 15 |
| LVDP (cmH2O) | 110 ± 2 | 122 ± 6 | 112 ± 3 | 111 ± 3 | 111 ± 5 |
| dP/dtmax (cmH2O/s) | 5601 ± 152 | 5590 ± 323 | 5475 ± 211 | 5461 ± 288 | 4821 ± 170 |
| dP/dtmin (cmH2O/s) | 3172 ± 107 | 3414 ± 235 | 3258 ± 104 | 3039 ± 159 | 3115 ± 180 |
| RPP (cmH2O/min) | 38011 ± 1044 | 44738 ± 2417 | 41482 ± 1456 | 41942 ± 1584 | 38540 ± 945 |
| TIC (min) | 6.73 ± 0.42 | 4.35 ± 0.9* | 6.73 ± 0.42 | 6.13 ± 0.42 | 6.28 ± 0.78 |
| Cmax (cmH2O) | 77 ± 4 | 98 ± 15 | 75 ± 5 | 71 ± 7 | 72 ± 7 |
Heart rate, LVDP, RPP, dP/dtmax and dP/dtmin were as measured at the end of 40 min of baseline perfusion. Time to ischemic contracture (TIC) and maximum contracture (Cmax) were measured during 20 min global, no-flow ischemia.
*
P < 0.05 vs. WT.