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. 2011 Oct;25(10):3356–3365. doi: 10.1096/fj.10-179218

Figure 6.

Figure 6.

AMPK activation attenuates Ca2+ entry-induced permeability in the isolated lung. A) 4αPDD increases permeability in the isolated perfused lung (final, open bar vs. baseline, solid bar). Addition of AICAR to stimulate AMPK attenuates 4αPDD-induced lung permeability (final 4αPDD vs. final 4αPDD+AICAR). Pretreatment of the lung with AICAR before addition of 4αPDD does not prevent lung injury (final AICAR+4αPDD vs. final 4αPDD+AICAR). Baseline, initial Kf measurement; final, final Kf measurement (n=5 animals). *P < 0.05. B) 4αPDD does not stimulate AMPK activity (n=3). Values are means ± se.